BACTERIOLOGICAL PROFILE OF PYOGENIC MENINGITIS CASES IN TERTIARY CARE HOSPITAL
Meningitis is a Medical emergency, because of known high morbidity and mortality and long term neurological squealed early diagnosis and prompt treatment is extremely important. 100 CSF samples were collected from clinically suspected meningitis. Samples were processed in the laboratory and the organisms were identified as per standard procedures. Antibiotic sensitivity testing of all the isolates was done by Kirby Bauer’s disc diffusion method. All case records reviewed simultaneously for clinically, biochemically and cytologically to clinch the diagnosis. CSF gram staining and biochemical results were taken as gold standard. Out of 100 cases 14 cases were found to be cultured positive. Cultures grew Streptococcus pneumoniae in 21.4% cases, S. pneumoniae was the most common isolate. Staphylococcus aureus, CoNS and Streptococcus spp. were isolated in 14.2% cases each. Gram negative bacilli were responsible for 4 isolates (28.57%).
Acinetobacter was the most common isolate (21.42%) followed by Pseudomonas aeruginosa (7.14%). Streptococcus pneumoniae isolates exhibited 100% sensitivity to all drugs except, Co-trimoxazole, Cephalexin and Ciprofloxacin (66% sensitive). Staphylococcus aureus exhibited 50% sensitivity to all drugs. One isolate of Staphylococcus aureus showed resistant to all drugs except for Imipenem. Streptococcus spp. showed 100% sensitivity to all drugs except for Gentamicin (50%). Enterococcus showed 100% sensitivity to all drugs except Co-trimoxazole and Cephalexin showed resistance. A combination of CSF culture and microscopic examination is highly specific for early diagnosis of bacterial meningitis and performing an antibacterial sensitivity test is recommended before any antibiotic therapy.
Bhat BV , Verma IC , Puri RK, Srinivasan S, and Nalini P. (1991). “A profile of pyogenic meningitis in children”, J Indian Med Assoc, Vol.89, pp.224-226.
Carpenter RR, and Petersdorf RG. (1962). “The clinical spectrum of bacterial meningitis”, The Am J Med, Vol.33, pp.262-275.
Chinchalkar N, and Mane M. (2002). “Diagnosis and outcome of acute bacterial meningitis in early childhood”, Indian Pediatrics, Vol.39, pp.914-921.
Chowdhary V, Gulati P, Sachdev A, and Mittal S.K. (1991). “Pyogenic meningitis : sonographic evaluation”, Indian Pediatr, Vol.28, pp.749-755.
Devi SP, Murthy SN, Nathsharma kc, and Murthy US. (1982). “Etiological study of pyogenic meningitis in children by CIEP”, Indian Pediatr, Vol.19, pp.317-321.
Elizabeth RR. (1986). “Suppurative Bacterial Meningitis: A 6 years study”, Phil J Microbiol Infect Dis, Vol.Null, pp.73-76.
Fule RP, Powar RM, and Saoji AM. (1989). “Bacteriological profile of Acute pyogenic meningitis”, Indian Pediatr, Vol.26, pp.174-175.
Ghosh S, and Roy G. (1970). “Pyogenic meningitis in children”, J Indian Med Assoc, Vol.55, pp.230-236.
Gorse JJ, Thrupp LD, Nudleman KL, Wyle FA, Haukins B, and Cesario TC. (1984). “Bacterial meningitis in the elderly”, Arch Intern Med, Vol.144, pp.1603-1607.
Heycock JB, and Noble TC. (1964). “Pyogenic meningitis in infancy and childhood”, Br Med J, Vol.1, pp.658-662.
Kabra SK, Kumar P, Verma IC, Mukherjee D, Chowdhary BH, Sengupta S, Singh RN, Khatua SP, Miglani N, Sehai KM, Sharma D, Prakash K, Dutta AK, Patwari AK, Aneja S, and Chandra D. (1991). “Bacterial meningitis in India: an IJP survey”, Indian J Pediatr, Vol.58, pp.505-511.
Kakar BA. (2007). “Acute pyogenic Meningitis incidence in paedriatics”, Professional Med J Jun, Vol.14(2), pp.272-275.
Kumar L, Chitylangya S, and Ayyagiri A. (1980). “The current status of pyogenic meningitis in children”, Indian pediatr, Vol.17, pp.438-444.
Lee JH, CHO HK, and Kim KH. (2011). “Etiology of invasive bacterial infections in Korea 1996-2005; retrospective multicenter study”, J Korean Med Sci, Vol.26(2), pp.174-183.
Mani R, Pradhan S, Nagarathna S, and Asiwla R. (2007). “Bacterial profile of community acquired acute bacterial meningitis: A Ten year retrospective study in tertiary neurocare center in south India”, Indian Journal of Medical Microbiology, Vol.25(2), pp.108-114.
Marji S. (2007). “Bacterial meningitis in children”, Rawal Med J, Vol.32, pp.109-111.
Panjarathinam R, and Shah RK. (1993). “Pyogenic meningitis in Ahmedabad”, Indian journal of pediatrics, Vol.60, pp.669-673.
Rao BN, and Kashbur IM. (1998). “Etiology and occurrence of acute bacterial meningitis in children in Behghazi”, Libyan Arab. Vol.4, pp.50-57.
Sehgal H. (1972). “A comparative study of treatment of pyogenic meningitis with antimicrobial therapy in different combinations”, Indian Pediatr, Vol.9, pp.605-612.
Shameem S, Kumar V, and Neelagund YF. (2008). “Bacterial meningitis rapid diagnosis and microbial profile; a multicenter study”, J common Dis, Vol.40, pp.111-120.
Sonavane A, Baradkar VP, and Mathur M. (2008). “Bacteriological profile of pyogenic meningitis in adults”, Bombay Hospital Journal, Vol.50(3), pp.452-455.
Swartz MN, and Dodge PR. (1965). “Bacterial meningitis - A review of selected aspects”, N Engl J Med, Vol.272, pp.725-730.
Tankhiwale SS, Jagtap PM, and Khadse RK. (2001). “Bacteriological study of pyogenic meningitis with special reference to C-ractive protein”, Indian journal of medical microbiology, Vol.19(3), pp.150-160.
Vashi N, and Joshi A. (1968). “The changing pattern of purulent meningitis”, Indian Pediatr, Vol.5, pp.444-455.
Zamanzad B, and Shirzadeh H. (2003). “Bacteriology and sensitivity patterns of acute adult bacterial meningitis. A seven year overview”, Kuwait Medical Journal, Vol.35(2), pp.122-125.
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