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Surendra Kumar Jinger, Mamta Choudary, Yogita Soni, Ghanshyam Gahlot


The association of serum trace elements like selenium, zinc, manganese and copper has been found in patients with thyroid dysfunctions. This study was conducted to see the serum level of these four trace elements in hypothyroid patients and Serum levels of free T3, T4 and TSH detection by chemilumminisence method of confirmed 95 hypothyroid patients (28 males, 67 females), and results was compared with age and sex matched 95 healthy subjects were included in this study. Both control and study group patients were of same socio-economic status and dietary habits. Serum levels of zinc, manganese and copper were estimated using standard absorption spectrophotometer technique and serum level of selenium by hydride generation method. We observed significant low serum levels of zinc, copper and selenium, while high level of serum manganese in hypothyroidism patients, as compared with normal healthy controls. The result showed a significant association of trace elements with hypothyroidism.


Hypothyroidism, Trace elements, Thyroid hormone, Atomic absorption spectrophotometer, Hydride generation method, Chemilumminisence immune assay.

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