A STUDY OF CLINICAL OUTCOME OF INDUCTION CHEMOTHERAPY IN LOCALLY ADVANCED HEAD AND NECK CARCINOMA IN CENTRAL INDIA
Aim of this study is to analyse the clinical profile of locally advanced oral carcinoma and to compare the prognosis of patients who underwent neoadjuvant chemotherapy followed by surgery to that of those who underwent primary surgery.
Material and Methods: It was a Prospective, Randomized study done in the Department of Surgery and Oncology, Chirayu Medical college and hospital Bhopal from November 2012 to November 2017.Patients Population studied was 50 (25 in each arm).
Results: Most common age group was 40-49 years, with median age of 44 years in both the arms. Ulcer and trismus were the most common symptoms in both the arms, about 95% and 60% respectively, with median duration of 3 months. Most common lesions were ulcero-proliferative (61%) arising from gingivi- buccal complex and ulcero- infiltrative (39%) with median diameter of 4 cm and skin involvement of 5cm. In this study following neo-adjuvant chemotherapy 19 out of 25 patients(76%) had partial response, 2 patients (8%) had complete response to NACT, 3 patients(12 %) had stable disease and 1 patient (4%) had progression of disease despite two/three cycles of NACT.Conclusion: It has been suggested that in the advent of newer chemotherapy molecules and regimens and more aggressive drug combinations might result in survival benefit after NACT schedule. This study convincingly demonstrated the feasibility of induction chemotherapy with acceptable results.
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