ADJUVANT CHEMOTHERAPY VERSUS NO CHEMOTHERAPY IN PATIENTS OF GALL BLADDER CARCINOMA TREATED WITH RADICAL CHOLECYSTECTOMY – A COMPARATIVE STUDY ON DISEASE FREE SURVIVAL AND QUALITY OF LIFE
Background: The beneficial effects, if any, of adjuvant chemotherapy in terms of disease free survival (DFS) and quality of life (QOL) in patients of gall bladder carcinoma following radical cholecystectomy have not been adequately studied so far.
Objectives: We conducted this study to look into various parameters of QOL and DFS of gall bladder malignancy who received chemotherapy after radical cholecystectomy vis-à-vis the cases who did not receive perioperative chemotherapy.
Methodology: Total 30 cases were selected and divided into two groups – Group A (n=12 patients who underwent radical cholecystectomy alone) and Group B (n = 18 patients who received perioperative chemotherapy). The patients were followed up for 18 months on various parameters of QOL and DFS according to the FACT HEP questionnaire.
Results: The mean age of our patients was 54 years and 76.71% were females. Most of the patients presented to us at stage III (46.7%) and stage II (36.7%). The mean physical. functional, social and emotional wellbeing scores were better in the adjuvant chemotherapy group but the differences were not statistically significant. Statistically significant association (p value 0.0003) was found between survival and the stage at presentation.
Conclusion: QOL represented by physical, emotional, functional and additional concern parameters was generally in favour of chemotherapy group although statistically not significant. DFS was mostly dependent on stage at presentation. The small sample size and nonrandomized study with short duration follow up and single institutional data were the major limitations of the study.
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