CLINICAL, RADIOLOGICAL AND INTRA-OPERATIVE PREDICTORS OF CHOLEDOCHOLITHIASIS: A PROSPECTIVE STUDY
Abstract
Background- CBD stones are a frequent complication in cholelithiasis & biliary pancreatitis. Accurate preoperative diagnosis aids in deciding the modality of intervention.
Material and Methods - We did a prospective study in a tertiary care hospital to determine the clinical, biochemical, radiological and intra-operative predictors of choledocholithiasis.
Results – Data of 134 patients with cholecystitis over a 2-year period was collected. With median age being 41.5 years, majority 99 (73.8%) were women. 55 patients had clinical indicators of choledocholithiasis, while 79 had none. Most common presentation was jaundice 30 (54.5%). Cholangitis had the highest specificity (100%) and an accuracy of 79.9%. Of patients with clinical indicators, 44 cholangiograms suggested stones, of which 41 was confirmed. Palpable stone in CBD was the best sensitivity 93%, specificity 100%, PPV 100%, NPV 96.8% and accuracy of 97.8%. Prior pancreatitis and cystic duct diameter of >4mm were the poorest predictors
Conclusion – Intra-op assessment was found to have the best sensitivity. Clinical criteria predict choledocholithiasis fairly accurately (false negative rate of 1.49%).
Keywords
References
Anderson MA, Fisher L, and Jain R, et al. (2012). “Complications of ERCP”, Gastrointest Endosc, Vol.75, pp.467-473. DOI: 10.1016/j.gie.2011.07.010
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, and Vege SS. (2013). “Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus”, Gut, Jan, Vol.62(1), pp.102-111.
Becker BA, Chin E, Mervis E, Anderson CL, Oshita MH, and Fox JC. (2014). “Emergency biliary sonography: utility of common bile duct measurement in the diagnosis of cholecystitis and choledocholithiasis”, J Emerg Med, Jan, Vol.46(1), pp.54-60.
Bose SM, Mazumdar A, Prakash SV, Kocher R, Katariya S, and Pathak CM. (2001). “Evaluation of the Predictors of Choledocholithiasis: Comparative Analysis of Clinical, Biochemical, Radiological, Radionuclear, and Intraoperative Parameters”, Surg Today, Vol.31, pp.117–122.
Committee asop, Maple JT, and Ben-Menachem T, et al. (2010). “The role of endoscopy in the evaluation of suspected choledocholithiasis”, Gastrointest Endosc, Vol.71, pp.1-9. DOI: 10.1016/j.gie.2009.09.041
Goldman L, Ausiello D. (2005). “Cecil Tratado de medicina interna”, 22, ed. Rio de Janeiro, Elsevier.
Hallalah, Amortegui JD, Jeroukhimov IM, Casillas J, Schulman CI, and Manning RJ, et al. (2005). “Magnetic resonance cholangiopancreatography accurately detects common bile Duct stones in resolving gall stone pancreatitis”, J Am Coll Surg, Vol.200, pp.869-875.
Jarhult J. (2005). “Is preoperative evaluation of the biliary tree necessary in uncomplicated gall stone disease”, Scand J Surg, Vol.94, pp.31-33.
Liu CL, Lo CM, and Chan JK, et al. (2001). “Detection of choledocholithiasis by EUS in acute pancreatitis: A prospective evaluation in 100 consecutive Patients”, Gastrointest Endosc, Vol.54, pp.325-330. DOI: 10.1067/ mge.2001.117513
Liu TH, Consorti ET, Kawashima A, Tamm EP, Kwong KL, and Gill BS, et al. (2001). “Patient evaluation and management with selective use of magnetic resonance cholangiography And endoscopic retrograde cholangiopancreatography before laparoscopic cholecystectomy”, Ann Surg, Vol.234, pp.33-40.
Metcalfe MS, Ong T, Bruening MH, Iswariah H, Wemyss-Holden SA, Maddern GJ. (2004). “Is laparoscopic intraoperative cholangiogram a matter of routine?”, Am J Surg, Vol.187, pp.475-481.
Mirizzi PL. (1937). “Operative cholangiography”, Surg Gynecol Obstet, Vol.65, pp.702-710.
O’Neill CJ, Gillies DM, and Gani JS. (2008). “Choledocholithiasis: Overdiagnosed endoscopically and undertreated laparoscopically”, ANZ J Surg, Vol.78, pp.487-491. DOI: 10.1111/j.1445-2197.2008.04540.x
Prat F, Amouyal G, Amouyal P, Pelletier G, Fritsch J, Choury AD, Buffet C, and Etienne JP. (1996). “Prospective controlled study of endoscopic ultrasonography and endoscopic retrograde cholangiography in patients with suspected common-bileduct lithiasis”, Lancet, Vol.347(8994), 13 January, pp.75-79. Https://doi.org/10.1016/S0140-6736(96)90208-1
Stain SC, Marsri LS, Froes ET, Sharma V, and Parekh D. (1994). “Laparoscopic cholecystectomy: laboratory predictors of choledocholithiasis”, The American Surgeon, 01 Oct, Vol.60(10), pp.767-771. (PMID:7944040)
Torres OJM, Cintra JCA, Cantanhede EB, Melo TCM, Macedo EL, and Dietz UA. (1997). “Ultrasonography value and of alkaline phosphatase in choledocholithiasis diagnosis”, JBM, Vol.73(4), pp.42-46.
Tozatti J, Mello ALP, and Frazon O. (2015). “Predictor Factors For Choledocholithiasis”, ABCD Arq Bras Cir Dig, Vol.28(2), pp.109-112. DOI: http://dx.doi.org/10.1590/S0102-67202015000200006
Vdehult Per, Sandblom G, and Rasmussen IC. (2009). “How reliable is introperative cholangiography as method for detecting common bile duct stones?”, Surg Endosc, Vol.23, pp.304-312.
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