SYSTEMATIC REVIEW OF SURGERY OF SOLITARY METASTASIS POST NEPHRECTOMY AND ITS SURVIVAL
Abstract
Renal cell Carcinoma is the twelfth common cancer worldwide with 338000 cases diagnosed in 2012. The recurrence rates after nephrectomy for RCC is about 20-30% and about 40% eventually dying from the cancer progression. This high rate of recurrence after nephrectomy underscores the importance of post-surgical surveillance. Metastasis can be synchronous or metachronous type and solitary or multiple in origin. Metastasis post nephrectomy tends present early or very late after surgery.
We carred out a review of solitary metastasis patients who have had surgery and study their survival time. Kaplan–Meier survival plot analysis was done to find out the cumulative time of survival for all the patients who have had solitary Metastatectomy. The Median and mean survival time for 225 patients from the time of solitary metastasis removal by surgery was about 43 months (95% CI, 38.2 to 47.7 Months) and 61 Months (95% CI, 46.8 to 75.2 Months) respectively. We present you the findings of the behaviour of RCC in terms of different sites of metastasis and its time taken underlying its indolent nature.
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References
Airoldi M, Succo G, Valente G, Cavalot A, Gabriele P, and Bumma C. (1995). "Head and neck metastases of renal cancer after nephrectomy: A report of 2 cases", Tumori, Vol.81(3), pp.213-214.
Azawi NH, Tesfalem H, Mosholt KS, Høyerup P, Jensen ES, Malchau E, and Fode M. (2016). "Recurrence rates and survival in a danish cohort with renal cell carcinoma", Dan Med J., Apr, Vol.63(4), pii.A5208. available online: http://www.ncbi.nlm.nih.gov/pubmed/27034180. Accessed 4/5/2016, 2016.
Bandi G, Wen CC, Moon TD, and Nakada SY. (2008). "Single center preliminary experience with hand-assisted laparoscopic resection of isolated renal cell carcinoma fossa recurrences", Urology. Vol.71(3), pp.495-499, discussion 499-500.
Boorjian SA, Crispen PL, Lohse CM, Leibovich BC, and Blute ML. (2008). "Surgical resection of isolated retroperitoneal lymph node recurrence of renal cell carcinoma following nephrectomy", J Urol, Vol.180(1), pp.99-103; discussion 103.
Chang WT, Chai CY, and Lee KT. (2004). "Unusual upper gastrointestinal bleeding due to late metastasis from renal cell carcinoma: A case report", Kaohsiung J Med Sci, Vol.20(3), pp.137-141.
Chin AI, Lam JS, Figlin RA, and Belldegrun AS. (2006). "Surveillance strategies for renal cell carcinoma patients following nephrectomy", Rev Urol, Vol.8(1), pp.1-7.
Cobo-Dols M, Ales-Diaz I, and Villar-Chamorro E, et al. (2006). "Solitary metastasis in a nasal fossa as the first manifestation of a renal carcinoma", Clin Transl Oncol, Vol.8(4), pp.298-300.
Featherstone JM, Bass P, Cumming J, and Smart CJ. (2006). "Solitary, late metastatic recurrence of renal cell carcinoma: Two extraordinary cases", Int J Urol, Vol.13(12), pp.1525-1527.
Fentie DD, Barrett PH, and Taranger LA. (2000). "Metastatic renal cell cancer after laparoscopic radical nephrectomy: Long-term follow-up", J Endourol, Vol.14(5), pp.407-411.
Fottner A, Szalantzy M, and Wirthmann L, et al. (2010). "Bone metastases from renal cell carcinoma: Patient survival after surgical treatment", BMC Musculoskelet Disord, Vol.11, pp.145-2474-11-145.
Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, and Zincke H. (2002). "An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: The SSIGN score", J Urol, Vol.168(6), pp.2395-2400.
Friberg S, and Nystrom A. (2015). "Cancer metastases: Early dissemination and late recurrences", Cancer Growth Metastasis, Vol.8, pp.43-49.
Gavallos G, Tawfik O, Herrell D, and Langenstroer P. (2003). "Renal-ovarian axis: A case report and review", Urology, Vol.62(4), p.749.
Gogus C, Kilic O, Tulunay O, Tulunay O, and Beduk Y. (2004). "Solitary metastasis of renal cell carcinoma to the parotid gland 10 years after radical nephrectomy", Int J Urol, Vol.11(10), pp.894-896.
Jadav AM, Thrumurthy SG, and DeSousa BA. (2010). "Solitary colonic metastasis from renal cell carcinoma presenting as a surgical emergency nine years post-nephrectomy", World J Surg Oncol, Vol.8, p.54, doi: 10.1186/1477-7819-8-54.
Jemal A, Murray T, and Ward E, et al. (2005). "Cancer statistics", CA Cancer J Clin. Vol.55(1), pp.10-30.
Kanzaki R, Higashiyama M, Okami J, and Kodama K. (2009). "Surgical treatment for patients with solitary metastasis in the mediastinal lymph node from renal cell carcinoma", Interact Cardiovasc Thorac Surg, Vol.8(4), pp.485-487.
Kawahara N, Tomita K, Murakami H, Demura S, Satomi K, and Atomi Y. (2009). "Total en bloc spondylectomy and a greater omentum pedicle flap for a large bone and soft tissue defect: Solitary lumbar metastasis from renal cell carcinoma", J Orthop Sci, Vol.14(6), pp.830-836.
Kidney cancer mortality statistics. Cancer research UK, available online: http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/kidney-cancer/mortality. Accessed 4/3/2016, 2016.
Kim SP, Weight CJ, and Leibovich BC, et al. (2011). "Outcomes and clinicopathologic variables associated with late recurrence after nephrectomy for localized renal cell carcinoma", Urology, Vol.78(5), pp.1101-1106.
Lam JS, Leppert JT, Figlin RA, and Belldegrun AS. (2005). "Surveillance following radical or partial nephrectomy for renal cell carcinoma", Curr Urol Rep, Vol.6(1), pp.7-18.
Lam JS, Shvarts O, Leppert JT, Figlin RA, and Belldegrun AS. (2005). "Renal cell carcinoma 2005: New frontiers in staging, prognostication and targeted molecular therapy", J Urol., Vol.173(6), pp.1853-1862.
Lam JS, Shvarts O, Leppert JT, Pantuck AJ, Figlin RA, and Belldegrun AS. (2005). "Postoperative surveillance protocol for patients with localized and locally advanced renal cell carcinoma based on a validated prognostic nomogram and risk group stratification system", J Urol, Vol.174(2), pp.466-472, discussion 472; quiz 801.
Lauro S, Lanzetta G, Bria E, Trasatti L, Costarelli L, and Vecchione A. (1998). "Contralateral solitary testis metastasis antedating renal cell carcinoma: A case-report and review", Anticancer Res., Vol.18(6B), pp.4683-4684.
Lordan JT, Fawcett WJ, and Karanjia ND. (2008). "Solitary liver metastasis of chromophobe renal cell carcinoma 20 years after nephrectomy treated by hepatic resection", Urology, Vol.72(1), pp.230.e5-230.e6.
Macmull S, Gokaraju K, Miles J, Blunn GW, Cannon SR, and Briggs TW. (2010). "Use of endoprosthetic diaphyseal replacement: A novel approach to management of extensive metastatic tumor of the midshaft radius", Tech Hand Up Extrem Surg, Vol.14(3), pp.183-186.
Mancini V, Battaglia M, and Lucarelli G, et al. (2008). "Unusual solitary metastasis of the ciliary body in renal cell carcinoma", Int J Urol, Vol.15(4), pp.363-365.
Matsumoto S, Kawaguchi N, and Kitagawa T, et al. (1984). "Solitary bone metastasis 24 years after removal of renal cell carcinoma", Gan No Rinsho, Vol.30(8), pp.965-967.
Matsuo M, Koga S, and Nishikido M, et al. (2002). "Renal cell carcinoma with solitary metachronous metastasis to the urinary bladder", Urology, Vol.60(5), pp.911-912.
Minervini A, Salinitri G, Lera J, Caldarelli C, Caramella D, and Minervini R. (2004). "Solitary floating vena caval thrombus as a late recurrence of renal cell carcinoma", Int J Urol, Vol.11(4), pp.239-242.
Miyao N, Naito S, and Ozono S, et al. (2011). "Late recurrence of renal cell carcinoma: Retrospective and collaborative study of the japanese society of renal cancer", Urology, Vol.77(2), pp.379-384.
Moudouni SM, Tligui M, Doublet JD, Haab F, Gattegno B, and Thibault P. (2006). "Late metastasis of renal cell carcinoma to the submaxillary gland 10 years after radical nephrectomy", Int J Urol, Vol.13(4), pp.431-432.
Namikawa T, Iwabu J, Kitagawa H, Okabayashi T, Kobayashi M, and Hanazaki K. (2012). "Solitary gastric metastasis from a renal cell carcinoma, presenting 23 years after radical nephrectomy", Endoscopy, Vol.44, Suppl 2, UCTN:E177-8.
Namikawa T, Munekage M, Kitagawa H, Okabayashi T, Kobayashi M, and Hanazaki K. (2012). "Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease", Oncol Lett, Vol.4(4), pp.631-636.
Roser F, Rosahl SK, and Samii M. (2002). "Single cerebral metastasis 3 and 19 years after primary renal cell carcinoma: Case report and review of the literature", J Neurol Neurosurg Psychiatry, Vol.72(2), pp.257-258.
Sadatomo T, Yuki K, Migita K, Taniguchi E, Kodama Y, and Kurisu K. (2005). "Solitary brain metastasis from renal cell carcinoma 15 years after nephrectomy: Case report", Neurol Med Chir (Tokyo), Vol.45(8), pp.423-427.
Satomi Y. (1973). "A clinical study of the prognosis of renal carcinoma--with reference to factors on the part of host", Nihon Hinyokika Gakkai Zasshi, Vol.64(3), pp.195-216.
Schuurman W, and Willems WJ. (2009). "Lateral ankle reconstruction using a patellar tendon graft: A case report", J Foot Ankle Surg, Vol.48(3), pp.353-357.
Serouya SM, Dultz LA, Concors SJ, Wang B, and Patel KN. (2012). "Late solitary metastasis of renal cell carcinoma to the submandibular gland", J Oral Maxillofac Surg, Vol.70(10), pp.2356-2359.
Siriwardana HP, Harvey MH, Kadirkamanathan SS, Tang B, Kamel D, and Radzioch R. (2012). "Endoscopic mucosal resection of a solitary metastatic tumor in the stomach: A case report", Surg Laparosc Endosc Percutan Tech, Vol.22(3), p.e132-e134.
Sugasawa H, Ichikura T, and Ono S, et al. (2010). "Isolated gastric metastasis from renal cell carcinoma 19 years after radical nephrectomy", Int J Clin Oncol, Vol.15(2), pp.196-200.
Szendroi A, Dinya E, and Kardos M, et al. (2010). "Prognostic factors and survival of renal clear cell carcinoma patients with bone metastases", Pathol Oncol Res, Vol.16(1), pp.29-38.
Taira H, Ishii T, Inoue Y, and Hiratsuka Y. (2005). "Solitary psoas muscle metastasis after radical nephrectomy for renal cell carcinoma", Int J Urol, Vol.12(1), pp.96-97.
Tanikawa K, and Matsushita K. (1990). "Bladder metastasis from renal cell carcinoma three years after nephrectomy", Hinyokika Kiyo, Vol.36(8), pp.927-929.
Tapper H, Klein H, Rubenstein W, Intriere L, Choi Y, and Kazam E. (1997). "Recurrent renal cell carcinoma after 45 years", Clin Imaging, Vol.21(4), pp.273-275.
Tilki D, Hu B, and Nguyen HG, et al. (2015). "Impact of synchronous metastasis distribution on cancer specific survival in renal cell carcinoma after radical nephrectomy with tumor thrombectomy", J Urol, Vol.193(2), pp.436-442.
Varga M, Oliverius M, and Valsamis A, et al. (2009). "Pancreatic resection for metastatic renal cell carcinoma", Klin Onkol, Vol.22(6), pp.288-290.
Vasselli JR, Yang JC, Linehan WM, White DE, Rosenberg SA, and Walther MM. (2001). "Lack of retroperitoneal lymphadenopathy predicts survival of patients with metastatic renal cell carcinoma", J Urol, Vol.166(1), pp.68-72.
Walter CW, and Gillespie DR. (1960). "Metastatic hypernephroma of fifty years' duration", Minn Med, Vol.43, pp.123-125.
Wang H, Zhou N, and Xu X, et al. (2014). "Surgical treatment of bone metastases from renal cell carcinoma", Zhonghua Yi Xue Za Zhi, Vol.94(4), pp.289-292.
Yavascaoglu I, Korun N, Oktay B, Simsek U, and Ozyurt M. (1999). "Renal cell carcinoma with solitary synchronous pancreaticoduodenal and metachronous periprostatic metastases: Report of a case", Surg Today, Vol.29(4), pp.364-366.
Yetkin G, Uludag M, and Ozagari A. (2008). "Solitary colonic metastasis of renal cell carcinoma", Acta Chir Belg, Vol.108(2), pp.264-265.
Zisman A, Pantuck AJ, and Dorey F, et al. (2001). "Improved prognostication of renal cell carcinoma using an integrated staging system", J Clin Oncol, Vol.19(6), pp.1649-1657.
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